The two alien characters in the Simpsons are named after a Klingon warrior and "Kodos the Executioner" in the original Star Trek series

Highlighting his dictatorial proclivities, Milhouse's full name is Milhouse Mussolini Van Houten

Krusty the Clown was originally intended to be Homer's secret identity

Harry Shearer, who provided the voice for Mr. Burns, stated that he modeled the sound of Mr. Burn's voice in part on Ronald Reagan

Matt Groening revealed that the yellow color of characters on the Simpsons was chosen to make the show stand out when channel surfers were flipping through the channels

Conan O'Brien was a writer for the Simpsons between 1991 and 1993