Mr. Mackey is based on Trey Parker's school counselor Mr. Lackey

Casa Bonita from South Park is a real restaurant in Denver

South Park holds the Guinness World Record for "Most Swearing in an Animated Series."

Deforest Kelley, who played Dr. McCoy was considered for the role of Spock

James Doohan, who played Scotty, was a war hero who stormed Juno beaches during WWII. He lost the middle finger on his right hand during his service