Rick and Morty is based on the short "The Real Animated Adventures of Doc and Mharti", which was a parody of Back to the Future

The show’s creators met doing underground comedy in Los Angeles

The Rick and Morty character Bird Person is a parody of "The Hawk" from Buck Rogers

Rick and Morty co-creator Justin Roiland initially intended for Rick's actions to destroy the Earth in every episode

Justin Roiland created the song Get Schwifty when he was a kid

Justin Roiland, voice actor for Rick, had to burp so many times during the pilot episode that he developed a stomach ache so bad that he considered going to the hospital