When George Clooney requested a guest starring role in Southpark, he was offered a role as Stan's dog. He accepted, providing his best barking dog impersonation

Casa Bonita from South Park is a real restaurant in Denver

There is an alien hidden in every episode

South Park holds the Guinness World Record for "Most Swearing in an Animated Series."

Cartman's promiscuous mom was named after Trey Parker's unfaithful ex-fiance.

The Southpark character Chef was based on a dining hall employee who creators Matt and Trey knew from their college days