Despite Kenny's muffled voice in Southpark, all of Kenny's lines are scripted

Mr. Mackey is based on Trey Parker's school counselor Mr. Lackey

When George Clooney requested a guest starring role in Southpark, he was offered a role as Stan's dog. He accepted, providing his best barking dog impersonation

There is an alien hidden in every episode

South Park holds the Guinness World Record for "Most Swearing in an Animated Series."