Cartman's promiscuous mom was named after Trey Parker's unfaithful ex-fiance.

The Southpark character Chef was based on a dining hall employee who creators Matt and Trey knew from their college days

The first Southpark episode was created via stop motion using construction paper cutouts

Southpark character Butters Stough is based on the show's animation director Eric Stough

Despite Kenny's muffled voice in Southpark, all of Kenny's lines are scripted

Mr. Mackey is based on Trey Parker's school counselor Mr. Lackey