The Southpark character Chef was based on a dining hall employee who creators Matt and Trey knew from their college days

The first Southpark episode was created via stop motion using construction paper cutouts

It takes 5 days to create a Southpark episode

Despite Kenny's muffled voice in Southpark, all of Kenny's lines are scripted

Mr. Mackey is based on Trey Parker's school counselor Mr. Lackey

When George Clooney requested a guest starring role in Southpark, he was offered a role as Stan's dog. He accepted, providing his best barking dog impersonation